Ancestor v1.1
Computational inference of ancestral genomes
Step 1 - Insert a DNA multiples sequence alignment (MSA) in FASTA format

Insert Mycobacteriophage (Sample1)
Insert cyclin-dependent kinase 8 sample(Sample2)

or upload a file

Multiple sequence alignment : sequences are already aligned
Step 2- Insert tree in NEWICK format

or upload a file

Root tree tree is already rooted
Advanced options

Step 3 - Choose inference method

The best exact scenario

The best heuristique scenario

Absolute Proportional

The exact posterior decoding

The heuristique posterior decoding

Absolute proportional

Tree Hidden Markov Model probabilities (%)
Insertion Start
Insertion Extension

Deletion Start
Deletion Extension

Ancestors 1.0: a web server for ancestral sequence reconstruction.

Diallo AB, Makarenkov V, Blanchette M.

Bioinformatics. 2010 Jan 1;26(1):130-1. Epub 2009 Oct 22.PMID: 19850756 [PubMed - indexed for MEDLINE]

Exact and heuristic algorithms for the Indel Maximum Likelihood Problem.

Diallo AB, Makarenkov V, Blanchette M.

J Comput Biol. 2007 May;14(4):446-61.PMID: 17572023 [PubMed - indexed for MEDLINE]

Ancestor Web interface by : Etienne Lord

News (Updated 14 July 2011)

  • New: Ancestor was used in a reconstruction of the ancestral primate XIST locus.

    Horvath JE, Sheedy CB, Merrett SL, Diallo AB, Swofford DL,
    Nisc Comparative Sequencing Program, Green ED, Willard HF. Comparative analysis of the primate X-inactivation center region and reconstruction of the ancestral primate XIST locus.
    Genome Res. 2011 Jun;21(6)
    Pubmed PMID 21518738
  • Ancestor v1.1 (better estimation of Indels)
  • Results can be downloaded as a single .ZIP file. (2 February 2010)
  • Results view with the species tree (2 February 2010)
  • Option for multiple sequences alignment (MSA) here. (2 February 2010)
  • Option for rooting directly the trees here. (2 February 2010)

Notice (Updated 14 July 2011)

Important: Currently Ancestor v1.0 only support DNA samples.